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Stimulation of interleukin-1 and -6 production in alveolar macrophages by neotropical liana Uncaria tomentosa (Uv±a de Gato)

Journal Article

Lemaire I; Assinewe V; Cano P; Awang D; Arnason J

1999

Journal of Ethnopharmacology

64

109-115

Two extracts of different collections of the traditional medicine uv±a de gato (Uncaria tomentosa) from Peru were characterized by High Pressure Liquid Chromatography as containing approximately 6 mg/g total oxindole content prior to studies with alveolar macrophages. The plant preparations greatly stimulated IL-1 and IL-6 production by rat macrophages in a dose dependent manner in the range of 0.025‚Äì0.1 mg/ml. They were also able to enhance IL-1 and -6 in lipopolysaccharide-stimulated macrophages. The results suggest a strong immunostimulant action of this plant.

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Support

The Liana Ecology Project is supported by Marquette University and funded in part by the National Science Foundation.