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Cytotoxic diterpenoids from two lianas from the Suriname rainforest

Journal Article

Adou E; Williams R; Schilling J; Malone S; Meyer J; Wisse J; Frederik D; Koese D; Werkhoven M; Snipes C; Werk T; Kingston D

‚Äč

2005

Bioorganic & Medicinal Chemistry

13

6009-6014

Bioassay-guided fractionation of the MeOH and EtOAc fractions of extracts of two lianas collected in Suriname has led to the isolation of five new diterpenoids humirianthone 1 1-hydroxy-humirianthone 2 15R-humirianthol 3 patagonol 4 and patagonal 5 and the five known diterpenoids humirianthol 7 annonalide 8 acrenol 9 icacinol 10 and the oxidized annonalide 11. All 10 diterpenoids showed cytotoxic activity against the A2780 human ovarian cancer cell line and compounds 1 3 8 and 9 also showed activity against phytopathogenic fungi.

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Support

The Liana Ecology Project is supported by Marquette University and funded in part by the National Science Foundation.